报告题目：Data-driven mechanistic population pharmacokinetic modeling of oral ibuprofen
报 告 人：吴孝钿 教授
报告时间：2025年11月27日（星期四）上午10:00-11:00
报告地点：第四教学楼102教室
报告摘要：Ibuprofen, a commonly used non-steroidal anti-inflammatory drug (NSAID), exhibits considerable variability in pharmacokinetics following oral administration, particularly during the absorption phase. This study aimed to enhance the mechanistic understanding of ibuprofen absorption by developing and integrating physiologically-informed models of absorption within a population pharmacokinetic (PopPK) framework. Using existing datasets of ibuprofen plasma concentrations, two one-compartment PopPK models with linear elimination were developed: the Sequential Absorption Pharmacokinetic (SAPK) model, which accounts for pH-dependent gastrointestinal absorption, and the Partial Absorption Pharmacokinetic (PAPK) model, which reflects absorption triggered by gastric emptying. Both models adequately described the observed concentration-time profiles and explained individual variability in absorption. These findings offer valuable insight into ibuprofen absorption kinetics and support the advancement of personalized dosing strategies. This is a joint work with Zhejiang Conba Pharmaceutical Company.
报告人简介: 吴孝钿，上海海事大学理学院教授，博士生导师。本硕博分别毕业于西北工业大学，复旦大学和加拿大约克大学应用数学专业，曾在加拿大西安大略大学应用数学系和蒙特利尔大学药学院从事博士后研究。主要从事微分方程动力系统、经媒介传播的传染病预防和控制、以及基于模型/数据的药物动力学建模、分析与模拟研究。在Environmental Health Perspectives (EHP)、Journal of Pharmacokinetics and Pharmacodynamics (JPKPD)、Journal of Mathematical Biology (JMB)、Bulletin of Mathematical Biology (BMB), Journal of Theoretical Biology (JTB)、Mathematical Biosciences (MBS)等环境科学、药学和生物数学的知名学术期刊发表SCI论文40多篇。先后主持国家自然科学基金（NSFC）青年、面上项目，以及海外加拿大自然科学与工程基金博士后项目（FRQNT），参与项目多项。