报告题目：Original Antigenic Sin in CD4+ T Cells
报 告 人：马君岭 教授
报告时间：2025年5月20日（星期二）上午10:50-11:40
报告地点：上海理工大学管理学院，四楼第二会议室
报告摘要：Original antigenic sin (OAS) is the phenomenon where prior exposure to an antigen results in a decreased adaptive antibody response to a heterologous infection. This phenomenon may negatively impact the effectiveness of immunity acquired from vaccination or previous infections. We demonstrate that this phenomenon arises because the proliferation and regulation signals of CD4+ T cells are antigen-nonspecific. Fast-responding memory CD4+ T cells trigger a regulatory T cell (Treg) response, which prematurely suppresses the naïve CD4+ T cell response, leading to a similar OAS effect in CD4+ T cells. We illustrate this mechanism using a mathematical model that incorporates the proliferation of naïve and memory CD4+ T cells, interleukin-2 (IL-2), and Tregs. Our model is calibrated with experimental data and uses numerical simulations to study how the CD4+ T cell response varies with the level of cross-reactivity between memory CD4+ T cells and the antigen causing the secondary infection. Our results indicate that the immune response is weakest at an intermediate level of cross-reactivity, a key feature of OAS. This mechanism can also explain OAS in antibody responses.
报告人简介: Dr. Junling Ma于2003年获得普林斯顿大学博士学位。现为加拿大维多利亚大学数学与统计系教授。从事生物数学方面研究。主要研究方向有传染病动力学，公共卫生政策，免疫系统动力学，生态系统等。文章发表在Nature Communications, Proceedings of National Academy of Sciences, PLoS Computational Biology, Frontiers of Computational Neurosciences, Immunology, Infectious Disease Modeling, Mathematical Biosciences, Journal of Mathematical Biology, Journal of Theoretical Biology等期刊。