北京大学张磊教授学术报告

发布者:陈贝西发布时间:2025-10-07浏览次数:10


报告题目:Unveiling the Multistability of Complex Biological Systems: A New Horizon in the Solution Landscape

报 告 人:张  磊 教授

报告时间:20251011日 上午10:30-11:30

报告地点:上海理工大学 卓越楼810会议室

报告摘要:Biological systems are often characterized by nonlinear interactions, feedback loops, and the ability to adapt and evolve, making them challenging to study and model. The Waddington landscape has been widely applied to many biological systems. A long standing problem in computational mathematics is how to search for the entire family tree of possible stationary states without unwanted random guesses? Here we introduce a novel concept “Solution Landscape”, which is a pathway map consisting of all stationary points and their connections. We develop a generic and efficient saddle dynamics method to construct the solution landscape, which not only identifies all possible stationary states, but also reveals the connections between them. As illustrations, we apply the solution landscape approach to study two problems: One is to investigate the solution landscape of reaction-diffusion systems, which reveals a nonlinear mechanism for pattern formation beyond Turing instability, and the other one is construction of a blueprint of cell fate decision via Hyper Solution Landscape.

报告人简介张磊,北京大学北京国际数学研究中心博雅特聘教授,定量生物学中心、国际机器学习中心PI2001年本科毕业于北京大学,2004年在中科院数学与系统科学研究院获硕士学位,2008年在美国宾州州立大学获博士学位。研究领域为计算和应用数学、交叉科学,包括稀有事件与解景观的算法与应用,数学与生命科学交叉,计算材料科学等。研究成果PRLPNASActa NumericaCell Systems, Nature Communications, Science AdvancesSIAM系列期刊发表。()主持国家基金委创新研究群体、国家杰出青年科学基金、科技部重点研发专项、基金委原创探索计划、基金委优秀青年科学基金、中组部高层次青年人才计划等项目。2027年国际工业与应用数学大会(ICIAM)大会邀请报告人,曾获第二届王选杰出青年学者奖、英国皇家学会牛顿高级学者,目前担任“计算数学”副主编,SIAM J. Appl. Math, Science China Mathematics, CSIAM Trans. Appl. MathThe Innovation, Quantitative Biology8国内外期刊的编委。


上海理工大学系统科学高水平优势学科、理学院数学与生命科学交叉研究中心联合主办